Although Thoracic SMARCA4-deficient undifferentiated tumour (SD-UT) is a recognized entity in the 5th edition of the WHO classification of thoracic tumors, this alteration occurs in garden-variety lung cancer as well (and in many other tumors too!) In fact, it is likely SD-UT exists on a continuum with SMARCA4-deficient lung cancer. I recently came across an… Continue reading SMARCA4-deficiency: a continuum
Category: Pulmonary
FET::CREB fusion in a lung nodule
The list of tumours with fusions involving the FET (EWSR1, FUS) and CREB (CREB1, ATF1, or CREM) families of genes is ever-expanding. These are promiscuous genes that drive neoplasia in a wide variety of anatomical sites, often without being recognized as such – but that doesn’t mean tumours with these molecular lesions are always primary… Continue reading FET::CREB fusion in a lung nodule